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KMID : 0370220120560030158
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Yakhak Hoeji
2012 Volume.56 No. 3 p.158 ~ p.163
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LC/MS/MS Method for the Determination of Lidocaine in Hairless Rat Plasma and Pharmacokinetic Applications of Lidocaine Patch
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Hwang Ji-Yeon
Kim Chul-Jun
Shin Young-Hee
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Abstract
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Lidocaine has been studied for many chronic pain conditions, including postherpetic neuralgia (PHN) and recently it has also been increasingly used in transdermal drug delivery systems. In this study, pharmacokinetics of a lidocaine patch was studied in four hairless male rats. The plasma concentration was determined by a validated LC/MS/MS method after applying a (30mg) patch for 12 hours. From the plasma lidocaine concentration vs time curves, , Cmax, and Tmax of lidocaine patch were , , and , respectively.
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KEYWORD
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LC/MS/MS assay, lidocaine patch, pharmacokinetics, hairless rat
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